Clinical Evidence

Peer-Reviewed
Publications

As Lexington Medical grows, our customers around the globe see improved clinical outcomes verses previous stapling products. Surgeons have devoted time to both driving prospective studies and to collecting retrospective data in pursuit of objectively assessing AEON™ clinical performance versus the competition to determine whether AEON™ can deliver better outcomes for both patients and their institutions. The real-world evidence continues to mount as studies reveal the clinical superiority associated with our staple line.

Journal of The Society of Laparoscopic & Robotic Surgeons

Abstract

Background: Haemostasis-related complications associated with Medtronic Tri-staple^TM with preloaded buttress material and the novel, naked AEON^TMgastrointestinal staplers have not been extensively studied in bariatric surgery. The study aimed to assess and compare the 30-day haemostasis-related complications between Medtronic Tri-staple^TM and AEON^TM GIA staplers.

Materials and Methods: A retrospective analysis was performed on data from patients who underwent primary or revision sleeve gastrectomy (SG) or the sleeve component of single anastomosis duodeno-ileal bypass with SG (SADI-S) in a private hospital in Australia between November 2021 and December 2022. The surgeries were performed by a single surgeon, using either Medtronic Tri-staple^TM or AEON^TM staplers.

Results: The analysis included 250 patients, with the first 125 consecutive patients receiving staple line using the Medtronic Tri-staple^TM GIA stapler and the subsequent 125 patients receiving staple line using the AEON^TM GIA stapler. Statistical analysis revealed... Continue Reading

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques

Abstract

Background: As laparoscopic bariatric surgical techniques have matured, the incidence of complications has decreased over time. Surgical stapling devices are commonly used for resection and anastomosis of gastric tissue during bariatric surgery. The purpose of this study is to assess and compare complication rates and clinical outcomes between patient cohorts using 2 different approved stapling devices.

Materials and Methods: Clinical outcomes were retrospectively compared for patients undergoing bariatric surgery between April 2019 and December 2020 using laparoscopic surgical stapling device A (LSSD-A) against outcomes between January 2017 and September 2018 using laparoscopic surgical stapling device B (LSSD-B). Tradenames for LSSD-A and LSSD-B were AEON Endostapler and Endo GIA with Tri-Staple Technology, respectively.

Results: In all, 814 patients underwent laparoscopic bariatric operation using LSSD-A and 1034 using LSSD-B. Laparoscopic surgery included… Continue Reading

Frontiers in Oncology

Abstract

Background: The aim of this study is to investigate the effects of using a new innovative endovascular stapler, AEON™, on the pancreatic leak rates and other outcome measures.

Methods: In a retrospective review of prospectively collected data from a secure tertiary unit registry, patients undergoing distal or lateral pancreatectomy were analyzed for any differences on pancreatic fistula rates, length of stay, comprehensive complication index (CCI), and demographics after using AEON™ compared with other commonly used staplers. Statistical significance was defined as <0.05.

Results: There were no differences in the demographics between the two groups totaling 58 patients over 2 years from 2019 to 2021. A total of 43 and 15 patients underwent pancreatic transection using other staplers and AEON™ endovascular stapler, respectively. The comparison of the two groups revealed a significantly reduced rate of mean drain lipase at postoperative day 3 with AEON™ (446 U/L) versus the other staplers (4,208 U/L) (p = 0.018) and a subsequent reduction of… Continue Reading

Obesity Surgery

Abstract

Purpose: The development of Laparoscopic Linear Endostaplers (LLES) is crucial in minimally invasive approaches in bariatric surgery, but there have been very few published studies comparing 6-row LLES in Laparoscopic Sleeve Gastrectomy (LSG). The objective of this study was to compare two 6-row LLES in LSG.

Methods: A total of 60 patients were prospectively randomized to undergo LSG with either Medtronic Endo GIA™ Tri-Staple technology (MTS) or AEON ™ Endostapler(Lexington Medical) LLES. The measured parameters included patient demographics, comorbidity indices, LLES and specimen characteristics, postoperative symptoms, hospital stay, and total adverse events (AEs). Intraoperative bleeding was evaluated using five laparoscopic and corresponding endoscopic images of staple line before clip application, compared with a 1–5 Visual Analogue Scale (VAS), assessed by an independent bariatric surgeon who was blinded to the LLES used. Images of all cases were reviewed on the same day to increase test–retest reliability.

Results: Both groups were similar in patient demographics. Compared to MTS, AEON LLES group had significantly lower bleeding… Continue Reading

Journal of The Society of Laparoscopic & Robotic Surgeons

Abstract

Background: Staple line bleeding can be a major intra-operative complication during laparoscopic sleeve gastrectomy, requiring reinforcing interventions that may diminish the integrity of the staple line and put patients at risk for postoperative hemorrhage or leak. To improve outcomes associated with surgery, surgeons may benefit from an alternative stapler that produces a drier staple line and requires less staple line manipulation.

Methods: Sixty consecutive laparoscopic sleeve gastrectomy procedures were performed by three surgeons; 30 sleeves using the AEON™ Endostapler on THICK MODE and 30 using the Echelon Flex™ Powered Stapler with pulse technique. Stapler performance was measured by incidence and degree of staple line bleeding. Images of the first firing and fundus were taken with the laparoscope 10 seconds after the final firing. Images were evaluated by a third-party blinded evaluator and given a “bleeding score,” a qualitative measure of intra-operative staple-line bleeding (1 = no bleeding to 5 = profuse bleeding).

Results: The AEON™ Endostapler demonstrated a lower mean (± standard error) “bleeding score” versus the Echelon Flex™… Continue Reading

Interested in Collaborating?

We continuously seek surgeon partners who are interested in studying clinical outcomes associated with AEON™. Please share your proposed research project so we can continue to bring innovation to surgical stapling together.

Clinical Evidence

Peer-Reviewed
Publications

Comparative Analysis of Hemostasis and Staple-Line Integrity between Medtronic Tri-Staple with Preloaded Buttress Material and the AEON Stapler in Bariatric Surgery

Abstract

Evaluation of Alternate Laparoscopic Stapling Device for Bariatric Surgery

Abstract

Preliminary experience in laparoscopic distal pancreatectomy using the AEON™ endovascular stapler

Abstract

Prospective Randomized Comparison of Linear Endostaplers During Laparoscopic Sleeve Gastrectomy

Abstract

Improving Hemostasis in Sleeve Gastrectomy With Alternative Stapler

Abstract

Interested in Collaborating?

USA Headquarters

Sydney, Australia

London, United Kingdom

Wollerau, Switzerland

Contact Us

Clinical Evidence

Peer-ReviewedPublications

Comparative Analysis of Hemostasis and Staple-Line Integrity between Medtronic Tri-Staple with Preloaded Buttress Material and the AEON Stapler in Bariatric Surgery

Abstract

Evaluation of Alternate Laparoscopic Stapling Device for Bariatric Surgery

Abstract

Preliminary experience in laparoscopic distal pancreatectomy using the AEON™ endovascular stapler

Abstract

Prospective Randomized Comparison of Linear Endostaplers During Laparoscopic Sleeve Gastrectomy

Abstract

Improving Hemostasis in Sleeve Gastrectomy With Alternative Stapler

Abstract

Interested in Collaborating?

USA Headquarters

Sydney, Australia

London, United Kingdom

Wollerau, Switzerland

Contact Us

Peer-Reviewed
Publications